2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Sodium Channel

Sodium Channel

Na channels; Na+ channels

Sodium Channel

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Sodium channels are integral membrane proteins that form ion channels, conducting sodium ions (Na+) through a cell's plasma membrane. They are classified according to the trigger that opens the channel for such ions, i.e. either a voltage-change (Voltage-gated, voltage-sensitive, or voltage-dependent sodium channel also called VGSCs or Nav channel) or a binding of a substance (a ligand) to the channel (ligand-gated sodium channels). In excitable cells such as neurons, myocytes, and certain types of glia, sodium channels are responsible for the rising phase of action potentials. Voltage-gated Na+ channels can exist in any of three distinct states: deactivated (closed), activated (open), or inactivated (closed). Ligand-gated sodium channels are activated by binding of a ligand instead of a change in membrane potential.

Sodium Channel Isoform Specific Products:

Sodium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0185S
    N-Oxide Lidocaine-d10
    		Inhibitor
    N-Oxide Lidocaine-d10 is the deuterium labeled Lidocaine. Lidocaine (Lignocaine) inhibits sodium channels involving complex voltage and using dependence. Lidocaine decreases growth, migration and invasion of gastric carcinoma cells via up-regulating miR-145 expression and further inactivation of MEK/ERK and NF-κB signaling pathways. Lidocaine is an amide derivative and has potential for the research of ventricular arrhythmia.
    N-Oxide Lidocaine-d<sub>10</sub>
  • HY-B1280R
    Nikethamide (Standard)
    Nikethamide (Standard) is the analytical standard of Nikethamide. This product is intended for research and analytical applications. Nikethamide, one of the respiratory central stimulants, has the potential for respiratory failure research.
    Nikethamide (Standard)
  • HY-B0122S1
    Topiramate-13C
    		Inhibitor
    Topiramate-13C (McN 4853-13C) is 13C labeled Topiramate. Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase.
    Topiramate-<sup>13</sup>C<sub>
  • HY-172005
    10,11-Dihydroxycarbamazepine
    10,11-Dihydroxycarbamazepine is a metabolite of the anticonvulsant Carbamazepine (HY-B0246). Carbamazepine is an orally active pressure-sensitive sodium ion channel blocker.
    10,11-Dihydroxycarbamazepine
  • HY-B1288R
    Oxybuprocaine hydrochloride (Standard)
    		Inhibitor
    Oxybuprocaine (hydrochloride) (Standard) is the analytical standard of Oxybuprocaine (hydrochloride). This product is intended for research and analytical applications. Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology.
    Oxybuprocaine hydrochloride (Standard)
  • HY-W803860
    N-Depropylpropafenone
    		Antagonist
    N-Depropylpropafenone is an active metabolite of Propafenone (HY-B0432), generated through the CYP450 enzyme system (mainly CYP2D6). It functions by blocking sodium ion channels, slowing myocardial conduction and exhibiting certain antiarrhythmic effects.
    N-Depropylpropafenone
  • HY-107186
    EO-122
    		Antagonist
    EO-122 is a potent antagonist of calcium channel and sodium channel potentially for the research of arrhythmia.
    EO-122
  • HY-108505R
    QX-314 chloride (Standard)
    		Inhibitor
    QX-314 chloride (Standard) is the analytical standard of QX-314 (chloride) (HY-108505). This product is intended for research and analytical applications. QX-314 chloride is a membrane-impermeable permanently charged sodium channel blocker.
    QX-314 chloride (Standard)
  • HY-185335
    Sodium Channel-IN-8
    		Inhibitor
    Sodium Channel-IN-8 (Example 96) is a voltage-gated sodium channel (NaV1.7) inhibitor.Sodium Channel-IN-8 can be used for the research of pain.
    Sodium Channel-IN-8
  • HY-B1319R
    Pramocaine hydrochloride (Standard)
    		Inhibitor
    Pramocaine (hydrochloride) (Standard) is the analytical standard of Pramocaine (hydrochloride). This product is intended for research and analytical applications. Pramocaine hydrochloride decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses.
    Pramocaine hydrochloride (Standard)
  • HY-107405S
    TC-N 1752-d5
    		Inhibitor
    TC-N 1752-d5 is deuterium-labeled TC-N 1752 (HY-107405).
    TC-N 1752-d<sub>5</sub>
  • HY-A0236AR
    Aprindine hydrochloride (Standard)
    		Inhibitor
    Aprindine hydrochloride (Standard) is the analytical reference standard of Aprindine hydrochloride (HY-A0236A). This product is used for research and analytical applications. Aprindine hydrochloride is an Ib-class anti-arrhythmic agent. Aprindine hydrochloride mainly exerts its effect by blocking sodium channels (INa), thereby reducing the excitability and conduction velocity of cardiac muscle cells. Aprindine hydrochloride significantly inhibits delayed potassium currents, which helps to prolong the atrial effective refractory period (AERP) and inhibit the occurrence of atrial fibrillation. Aprindine hydrochloride can also regulate intracellular calcium ion concentration by inhibiting Na+/Ca2+ exchange current (INCX), thereby further stabilizing cardiac electrical activity. Aprindine hydrochloride can be used for the study of atrial fibrillation (AF) and ventricular arrhythmias.
    Aprindine hydrochloride (Standard)
  • HY-108506S4
    Licarbazepine-d8
    		Inhibitor
    Licarbazepine-d8 (BIA 2-005-d8) is deuterium labeled Licarbazepine. Licarbazepine (BIA 2-005; GP 47779)?is a?voltage-gated sodium channel?blocker?with?anticonvulsant?and?mood-stabilizing?effects.
    Licarbazepine-d8
  • HY-135478A
    LY393615 free base
    		Inhibitor
    LY393615 (NCC1048) free base is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 free base has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research.
    LY393615 free base
  • HY-100080R
    A-887826 (Standard)
    		Inhibitor
    A-887826 (Standard) is the analytical standard of A-887826 (HY-100080). This product is intended for research and analytical applications. A-887826 is a potent, selective, oral bioavailable and voltage-dependent Na(v)1.8 sodium channel blocker with an IC50 of 11 nM . A-887826 attenuates neuropathic tactile allodynia in vivo.
    A-887826 (Standard)
  • HY-B0358R
    Flunarizine (Standard)
    		Inhibitor
    Flunarizine (Standard) is the analytical standard of Flunarizine. This product is intended for research and analytical applications. Flunarizine is a potent dual Na+/Ca2+ channel (T-type) blocker. Flunarizine is a D2 dopamine receptor antagonist. Flunarizine shows anticonvulsive and antimigraine activity, and peripheral vasodilator effects.
    Flunarizine (Standard)
  • HY-126645
    Atelopidtoxin
    		Inhibitor
    Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel.
    Atelopidtoxin
  • HY-B0432AS3
    Propafenone-d5 Ethyl hydrochloride
    		Inhibitor
    Propafenone-d5 Ethyl (hydrochloride) is the deuterium labeled Propafenone hydrochloride. Propafenone (SA-79）hydrochloride is a class of anti-arrhythmic medication, which treats illnesses associated with rapid heart beats such as atrial and ventricular arrhythmias.
    Propafenone-d<sub>5</sub> Ethyl hydrochloride
  • HY-106017
    Nerispirdine
    		Inhibitor
    Nerispirdine is an ion channel inhibitor with IC50s of 3.6, 3.7 and 11.9 μM against K(v)1.1, K(v)1.2 and voltage-dependent Na(+) channel, respectively. Nerispirdine is a 4-aminopyridine (4-AP, HY-B0604) derivative and can be utilized in research on neurological disorders.
    Nerispirdine
  • HY-B0262S1
    Methocarbamol-d3
    		Inhibitor 98.15%
    Methocarbamol-d3 is the deuterium labeled Methocarbamol. Methocarbamol is an orally active central muscle relaxant and blocks muscular Nav1.4 channel. Methocarbamol reversibly affects voltage dependence of inactivation of Nav1.4 channel. Methocarbamol has the potential for muscle spasms and pain syndromes research.
    Methocarbamol-d<sub>3</sub>
Cat. No. Product Name / Synonyms Application Reactivity
Sodium Channel Isoform Comparison

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